Understanding the Use of e-Prints on Reddit and 4chan's Politically Incorrect Board

The dissemination and reach of scientific knowledge have increased at a blistering pace. In this context, e-Print servers have played a central role by providing scientists with a rapid and open mechanism for disseminating research without waiting for the (lengthy) peer review process. While helping the scientific community in several ways, e-Print servers also provide scientific communicators and the general public with access to a wealth of knowledge without paying hefty subscription fees. This motivates us to study how e-Prints are positioned within Web community discussions. In this paper, we analyze data from two Web communities: 14 years of Reddit data and over 4 from 4chan's Politically Incorrect board. Our findings highlight the presence of e-Prints in both science-enthusiast and general-audience communities. Real-world events and distinct factors influence the e-Prints people's discussions;e.g., there was a surge of COVID-19-related research publications during the early months of the outbreak and increased references to e-Prints in online discussions. Text in e-Prints and in online discussions referencing them has a low similarity, suggesting that the latter are not exclusively talking about the findings in the former. Further, our analysis of a sample of threads highlights: 1) misinterpretation and generalization of research findings, 2) early research findings being amplified as a source for future predictions, and 3) questioning findings from a pseudoscientific e-Print. Overall, our work emphasizes the need to quickly and effectively validate non-peer-reviewed e-Prints that get substantial press/social media coverage to help mitigate wrongful interpretations of scientific outputs. © 2023 ACM.

Bird ringing and nest recording in Britain and Ireland in 2020

This is the 84th annual report of the British Trust for Ornithology’s Ringing Scheme, incorporating the report of the Nest Record Scheme and covering work carried out and data processed in 2020. An analysis of Curlew Numenius arquata ringing records was carried out to investigate recent declines. Results showed that survival rates are high, so current population declines are more likely to have been driven by low productivity. To reverse the recent population declines, breeding success would need to increase and effective conservation strategies will be needed to maintain the high levels of survival. We examined the potential opportunities and challenges of using winter ringing records to produce survival estimates, as well as other outputs such as age ratios and recruitment, by analysing 2 641 352 encounter records from the winters of 2007/08 to 2017/18: winter-to-winter survival analyses on adult birds were undertaken, initially on 44 species. Results indicated that fortnightly ringing sessions should yield sufficient data to produce useful survival estimates. This research identified a number of potential analytical and methodological options for future development. Covid-19 restrictions limited the amount of fieldwork carried out in 2020;consequently, only 72 CE sites submitted data for the year. Long-term (1984–2019) declines in abundance were observed for five migrant, one partial migrant and four resident species while long-term increases in abundance were recorded for two short-distance migrants and six resident species. Six species are exhibiting significant long-term declines in productivity while only Chaffinch Fringilla coelebs shows a significant long-term increase. Long-term trends in survival indicate increases for 10 species and declines for nine. Short-term trends, which compare the current year to the five-year mean (2015–19), show that the abundance of 10 species increased significantly in 2020, with three species being recorded in higher numbers than in any previous year since CES monitoring began. Significant decreases in abundance were recorded for only two species. Productivity decreased significantly for one migrant and five resident species in 2020;no species recorded a significant increase. Productivity was lower in 2020 than in any previous CES year for Blue Tit Cyanistes caeruleus and Great Tit Parus major. Significant changes in survival rate were observed in two species in 2020 compared to the five-year mean, with Bullfinch Pyrrhula pyrrhula increasing and Blackbird Turdus merula decreasing. A new habitat was added to the suite of standard CES habitats in 2020 in the first year of a Garden CES trial. Submissions were received from 92 sites. A new winter ringing project was also launched in 2020, following a similar methodology to CES. Submissions were received from 111 sites. The number of Retrapping Adults for Survival projects that were able to run and submit data in 2020 was 146, from 200 that were registered. In total, 60 species were monitored, with Pied Flycatcher Ficedula hypoleuca (20 projects), Starling Sturnus vulgaris (19), House Sparrow Passer domesticus (18), Sand Martin Riparia riparia (10) and Reed Warbler Acrocephalus scirpaceus (eight) the species most studied. A total of 930 091 birds were ringed during the year, comprising 98 500 nestlings, 523 777 first-year birds, 278 157 adults (birds in their second calendar year or older) and 29 657 birds whose age could not be determined. In addition, there were 212 414 recaptures of ringed birds at or near the ringing site. In total, 42 987 recoveries (birds found dead, recaptured or resighted at least 5 km from the place of ringing) of BTO-ringed birds were reported in 2020. The Appendix highlights a selection of recoveries that have extended our knowledge of movements, as well as longevity records established during the year. A total of 23 928 NRS submissions were received in 2020, far fewer than usual due to Covid-19 restrictions being in place during the height of the nesting season. As the seasonality of nest reco ds was biased towards the end of the breeding season, after Covid-19 restrictions had lifted, it was not possible to generate meaningful NRS trends for 2020. Permits or licences to disturb breeding birds on Schedule 1 of the Wildlife and Countryside Act 1981 (as amended) were prepared and issued to 611 ringers and nest recorders in 2020. During 2020, the use of special methods was authorised for 1182 marking projects and 146 trapping projects. © 2022 British Trust for Ornithology.

Effect of Social Networking on Real-World Events

The articles in this special issue focus on the emerging effects that social media can have on the real world. Social media has quickly become not just ubiquitous, but also integral to society. A large portion of social media's quick ascent was due to its modeling of real-world relationships, meaning the offline world informed the development and adoption of the online world. Recently, however, it has become apparent that this effect is not a one-way street. For example, the spread of mis- and disinformation, the spread of conspiracy theories, and the rise of extremism can all be attributed, in part, to social media. Most previous research has studied the real world and social media in isolation. However, these worlds are interconnected with each world having a substantial impact and influence on the other. For instance, hateful rhetoric disseminated via social media can encourage physical meetings that can quickly transform rhetoric into violent actions. Overall, it is of paramount importance, as a research community, to devote research resources into understanding and analyzing the exogenic effects of social media to the real world with the goal to further improves our lives.

Exploring concepts and current evidence of shared and self-care in the management of lower limb wounds

The SARS-Cov-2 (COVID-19) pandemic saw the introduction of safety measures such as social distancing, isolation and shielding. This has facilitated health care services transformation, particularly in tissue viability services, where a decrease in community nursing visits, limited outpatient appointments and few face-to-face GP appointments have increased the need for patients to be actively involved in their own care. Such a shift has contributed towards patients and health professionals (HCP) sharing treatment and care responsibilities to maintain the patients’ health. This shift brings about its own challenges, with patients requiring a degree of knowledge and skills of wound care to be able to confidently manage their wounds. The terms self-care, shared care and supported self-management are often used to refer to patient involvement in their treatment and care but a lack of consensus around the extent of patient involvement and an absence of strategic guidelines for shared or self-management of lower limb wounds contributes towards difficulties in understanding the extent of patient involvement. This paper provides a narrative review of current literature focused on shared, self or supported self-management practices and perceptions in the management of lower limb wounds. © 2021, OmniaMed Communications Ltd. All rights reserved.

Validation of roche immunoassay for severe acute respiratory coronavirus 2 in South Africa

Background: Serology testing is an important ancillary diagnostic to the reverse transcriptase polymerase chain reaction (RT-PCR) test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aimed to evaluate the performance of the Roche Elecsys™ chemiluminescent immunoassay (Rotkreuz, Switzerland), that detects antibodies against the SARS-CoV-2 nucleocapsid antigen, at an academic laboratory in South Africa. Methods: Serum samples were collected from 312 donors with confirmed positive SARS-CoV-2 RT-PCR tests, with approval from a large university’s human research ethics committee. Negative controls included samples stored prior to December 2019 and from patients who tested negative for SARS-CoV-2 on RT-PCR and were confirmed negative using multiple serology methods (n = 124). Samples were stored at –80 °C and analysed on a Roche cobas™ 602 autoanalyser. Results: Compared with RT-PCR, our evaluation revealed a specificity of 100% and overall sensitivity of 65.1%. The sensitivity in individuals > 14 days’ post-diagnosis was 72.6%, with the highest sensitivity 31–50 days’ post-diagnosis at 88.6%. Results were also compared with in-house serology tests that showed high agreement in majority of categories. Conclusions: The sensitivity at all-time points post-diagnosis was lower than reported in other studies, but sensitivity in appropriate cohorts approached 90% with a high specificity. The lower sensitivity at earlier time points or in individuals without symptomatology may indicate failure to produce antibodies, which was further supported by the comparison against in-house serology tests.

"go eat a bat, chang!": On the emergence of sinophobic behavior onweb communities in the face of COVID-19

The outbreak of the COVID-19 pandemic has changed our lives in unprecedented ways. In the face of the projected catastrophic consequences, most countries have enacted social distancing measures in an attempt to limit the spread of the virus. Under these conditions, the Web has become an indispensable medium for information acquisition, communication, and entertainment. At the same time, unfortunately, the Web is being exploited for the dissemination of potentially harmful and disturbing content, such as the spread of conspiracy theories and hateful speech towards specific ethnic groups, in particular towards Chinese people and people of Asian descent since COVID-19 is believed to have originated from China. In this paper, we make a first attempt to study the emergence of Sinophobic behavior on the Web during the outbreak of the COVID-19 pandemic. We collect two large datasets from Twitter and 4chan's Politically Incorrect board (/pol/) over a time period of approximately five months and analyze them to investigate whether there is a rise or important differences with regard to the dissemination of Sinophobic content. We find that COVID-19 indeed drives the rise of Sinophobia on the Web and that the dissemination of Sinophobic content is a cross-platform phenomenon: it exists on fringe Web communities like /pol/, and to a lesser extent on mainstream ones like Twitter. Using word embeddings over time, we characterize the evolution of Sinophobic slurs on both Twitter and /pol/. Finally, we find interesting differences in the context in which words related to Chinese people are used on the Web before and after the COVID-19 outbreak: on Twitter we observe a shift towards blaming China for the situation, while on /pol/ we find a shift towards using more (and new) Sinophobic slurs. © 2021 ACM.

Age, Disease Severity and Ethnicity Influence Humoral Responses in a Multi-Ethnic COVID-19 Cohort

The COVID-19 pandemic has affected all individuals across the globe in some way. Despite large numbers of reported seroprevalence studies, there remains a limited understanding of how the magnitude and epitope utilization of the humoral immune response to SARS-CoV-2 viral anti-gens varies within populations following natural infection. Here, we designed a quantitative, multi-epitope protein microarray comprising various nucleocapsid protein structural motifs, including two structural domains and three intrinsically disordered regions. Quantitative data from the microarray provided complete differentiation between cases and pre-pandemic controls (100% sensitivity and specificity) in a case-control cohort (n = 100). We then assessed the influence of disease severity, age, and ethnicity on the strength and breadth of the humoral response in a multi-ethnic cohort (n = 138). As expected, patients with severe disease showed significantly higher antibody titers and interestingly also had significantly broader epitope coverage. A significant increase in antibody titer and epitope coverage was observed with increasing age, in both mild and severe disease, which is promising for vaccine efficacy in older individuals. Additionally, we observed significant differences in the breadth and strength of the humoral immune response in relation to ethnicity, which may reflect differences in genetic and lifestyle factors. Furthermore, our data enabled localization of the immuno-dominant epitope to the C-terminal structural domain of the viral nucleocapsid protein in two independent cohorts. Overall, we have designed, validated, and tested an advanced serological assay that enables accurate quantitation of the humoral response post natural infection and that has revealed unexpected differences in the magnitude and epitope utilization within a population.

A Virtual Rapid Response Pathway for Risk Management through COVID-19

COVID-19 related restrictions made it necessary for mental health outpatient care to abruptly transition to virtual care. For some youth and families, multiple stresses related to isolation, loss of friend and family supports, school cancellation are exacerbated by financial stress, limited parenting skills and challenges with emotion regulation. Such situations put young people at risk for deteriorating mental health and conflictual family situations, which could lead to Emergency (ED) presentations, admission, and child protective service or police involvement. At-risk young people include current outpatients, those who have been referred but not seen, and patients presenting to ED. Methods: A system was developed for categorizing all patients as high, medium or low risk and an algorithm de-veloped as to level of intervention required for each. All patients on the waitlist were triaged for risk level. A pathway was developed to have high risk patients referred from ED seen virtually within 3 days and other high risk patients monitored closely. Patient flow was adjusted to allow flexible matching of capacity to demand. Return visits to ED and evaluation of patient satisfaction with virtual care were used as outcome measures. Results: Patients referred to the rapid response pathway were seen in a shorter time than had previously been the case. Fewer patients returned to the ED on multiple occasions. Conclusions: Development of systems for categorizing patient risk levels, development of a virtual rapid response pathway, and flexing capacity to meet demand has enabled flexible rapid response to high needs patients.

COVID-19 antibody testing: From hype to immunological reality.

The potential role for serological tests in the current COVID-19 pandemic has generated very considerable recent interest across many sectors worldwide, inter alia pathologists seeking additional weapons for their armoury of diagnostic tests; epidemiologists seeking tools to gain seroprevalence data that will inform improved models of the spread of disease; research scientists seeking tools to study the natural history of COVID-19 disease; vaccine developers seeking tools to assess vaccine efficacy in clinical trials; and companies and governments seeking tools to aid return-to-work decision-making. However, much of the local debate to date has centred on questions surrounding whether regulatory approval processes are limiting access to serological tests, and has not paused to consider the intrinsically limiting impact of underlying fundamental biology and immunology on where and how different COVID-19 serological tests can usefully be deployed in the response to the current pandemic. We review, from an immunological perspective, recent experimental evidence on the time-dependency of adaptive immune responses following SARS-CoV-2 infection and the impact of this on the sensitivity and specificity of COVID-19 antibody tests made at different time points post infection. We interpret this scientific evidence in terms of mooted clinical applications for current COVID-19 antibody tests in identifying acute infections, in confirming recent or past infections at the individual and population level, and in detecting re-infection and protective immunity. We conclude with guidance on where current COVID-19 antibody tests can make a genuine impact in the pandemic.